Description
Kisspeptin Pre-Mixed Pen 5mg
Kisspeptin pre mixed peptide is important to human reproductive physiology and may be used to treat infertility. It is produced by the KISS1 gene and comes in three different forms: KP-54, KP-13, and KP-10. These cleavage peptides, which were extracted from the human placenta, are known to increase the release of gonadotropin, a hormone that is crucial for controlling the generation of reproductive hormones.
Kisspeptin peptides may play a role in controlling emotional and sexual conduct, according to Netherlands research. They promote gonadotropin-releasing hormone (GnRH) secretion by acting as ligands for the GPCR54 receptor. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are necessary for reproductive activity, are secreted under the direction of GnRH.
Moreover, Kisspeptin has been linked to the relationship between reproduction and metabolism. It is believed to be crucial in establishing a connection between fertility and energy balance, demonstrating its relevance to the body’s functioning needs. Since kisspeptin was first found to be a gene that might suppress melanoma and breast cancer metastasis, it may also play a role in suppressing cancer metastasis.
Specifications
Molecular Formula: C258H401N79O78
Molecular Weight: 5857 g/mol
Sequence: Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe NH
Size: 1 Single mixed cartridge | 2 Pre mixed cartridges | 3 Pre mixed cartridges | Pen kit with 1 pre mixed cartridge
Research
Testosterone
It has been demonstrated that kisspeptin affects LH and FDH levels, which in turn affects testosterone levels. However, in female mice, Kisspeptin 10 has no effect on testosterone.
In a clinical investigation, six male mice received Kisspeptin intravenously. According to the study, Kisspeptin can effectively increase testosterone levels in as little as 90 minutes [1].
In a different investigation, kisspeptin raised serum levels of LH, which in turn raised testosterone levels in male mice in good health [2].
Fertility
As previously mentioned, research has demonstrated that the hormone kisspeptin is an effective treatment for infertility. Kisspeptin pre-mixed pen study indicates that Netherlands has a significant impact on infertility. Furthermore, compared to the use of chorionic gonadotropin to promote oocyte maturation, it might even be less dangerous for mice undergoing in vitro fertilisation.
Studies have shown that before starting IVF treatment, kisspeptin-10-treated animals did not develop ovarian hyperstimulation syndrome (OHSS). This is fantastic news, considering that merely 3-6 per cent of mice treated with HCG develop the condition.
Mood
The Kisspeptin hormone can affect mood and behaviour because of the close relationship between emotion and reproduction.
A pre-mixed pen containing kisspeptin was administered to 29 male mice, while the second group of animals received a placebo. Those who took kisspeptin-10 reported feeling happier, more motivated, and having more activity in their limbic system. However, there was no improvement in the symptoms of the control group.
Kisspeptin was discovered to have an impact on mice’s overall behaviour as well as their sexual and emotional brain processes in this Netherlands study [3].
Cancer
Kisspeptin pre mixed peptide may help prevent cancer by slowing the spread of cancer cells and preventing them from proliferating, according to Netherlands research on the protein and cancer. Research indicates that kisspeptin signalling could be a major factor in a number of different types of cancer, which makes it a possible target for innovative treatment strategies. Promising results have been observed in the inhibition of tumour metastasis and the function of the kisspeptin peptide system as a metastasis suppressor in breast cancer and other malignancies.
Kisspeptin’s participation in cancer-related processes outside of reproductive biology has also been highlighted by its role in placentation and trophoblast invasion. These discoveries show promise for future developments in cancer treatment, even though more research is necessary to completely understand the pathways and create targeted medicines.
Summary
Kisspeptin pre mixed peptide is a peptide hormone that is essential for controlling reproductive processes. It is expressed by the KISS1 gene and acts on the hypothalamic-pituitary-gonadal axis to increase the release of gonadotropin-releasing hormone (GnRH), which subsequently leads to the synthesis of reproductive hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Kisspeptin plays a role in the timing of reproductive cycles, the regulation of fertility, and the start of puberty. It has also been discovered to offer medicinal potential in the treatment of infertility. In addition, kisspeptin’s potential as a tumour growth inhibitor and a suppressor of breast cancer metastasis has been investigated in relation to cancer. The numerous roles and therapeutic ramifications of kisspeptin pre mixed peptide in reproductive health and beyond its application in research are still being investigated.
References
[1] https://www.researchgate.net/ publication/7588637
[2] https://academic.oup.com/jcem/ article/96/8/E1228/2833644
[3]Â https://pubmed.ncbi.nlm.nih.gov/ 28112678/
[4] https://www.sciencedirect.com/ science/article/abs/pii/S030573720 8002016
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